MITCHELL LAB

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Welcome to the Mitchell Lab

Our research investigates how the genome is folded and organised in the nucleus and how this organisation influences regulation of gene expression. We often think about transcription as occurring on a particular gene in a linear manner whereas the nucleus is a three dimension organelle into which the genome is folded and organised. Recent work has shown that all transcription occurs at discreet compartments within the nucleus, termed transcription factories, with genes moving in and out of these compartments as they are expressed and silenced. Furthermore, distal enhancers have been shown to physically contact the genes they regulate forming tissue-specific chromatin loops. Our lab uses a combination of Molecular Biology, Genome Editing and Cellular Imaging Techniques combined with genome-wide approaches and bioinformatics analysis to investigate the mechanisms that underlie tissue-specific regulation of gene expression and genome folding.

Mitchell Lab News

Professor Mitchell has been awarded tenure.

Our Genome Research paper: Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes is out!

Professor Jennifer Mitchell is the recipient of the inaugural Dorothy Shoichet Women Faculty in Science Award of Excellence.

Virlana Shchuka has been awarded a PGS-D fellowship from NSERC, awarded to high-calibre students who are engaged in doctoral programs in the natural sciences or engineering.

Congratulations to Virlana Shchuka on receiving the Duncan L. Gellatly Memorial Award for excellence in research.

OIRM New Ideas grant on 'Activating enhancers to improve reprogramming efficiency' awarded to the Mitchell Lab.

Mitchell Lab receives an NSERC Discovery Grant.

U of T Cell Biologists Discover On-Off Switch for Key Stem Cell Gene

Key stem cell gene controlled from afar, Canadian scientists discover

 

CIHR NSERC Ontario Research Fund CFI