Welcome to the Mitchell Lab

Our research investigates how the genome is folded and organised in the nucleus and how this organisation influences regulation of gene expression. We often think about transcription as occurring on a particular gene in a linear manner whereas the nucleus is a three dimension organelle into which the genome is folded and organised. Transcription occurs at discreet compartments within the nucleus, termed transcription factories, with genes moving in and out of these compartments as they are expressed and silenced. Furthermore, distal enhancers have been shown to physically contact the genes they regulate forming tissue-specific chromatin loops. Our lab uses a combination of Molecular Biology, Genome Editing and Cellular Imaging Techniques combined with genome-wide approaches and bioinformatics analysis to investigate the mechanisms that underlie tissue-specific regulation of gene expression and genome folding.

Mitchell Lab News

Professor Mitchell will be presenting her work at the Precision CRISPR Stem Cell Congress 2018, running from June 12-14 in Seattle, WA.

Congratulations to Lida Langroudi and Navroop Dhaliwal on being awarded a Medicine by Design Travel Award to present their work at ISSCR2018 in Melbourne, Australia

Congratulations to Dr Sakthi Moorthy on being awarded an OIRM Travel Award to present her research at ISSCR2018 in Melbourne, Australia.

Dr Moorthy gave a talk on her research at the New Mexico BioInformatics, Science and Technology (NMBIST) Symposium on Genome Editing in Santa Fe, New Mexico

Our Stem Cell Reports paper: KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency is out!

Professor Mitchell spoke at Human Genome Meeting 2018 in Yokohama, Japan

Professor Mitchell presented a talk on her research at the Keystone conference Precision Genome Editing with Programmable Nucleases. Dr Moorthy presented a poster.

Congratulations to Gurdeep Singh on being awarded the Zoology International Award from Cell & Systems Biology.

Professor Mitchell gave a talk on her research at the 4th Canadian Conference on Epigenetics - Mechanisms of Disease. Dr Macpherson presented a poster.

Professor Mitchell has been awarded tenure.

Our Genome Research paper: Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes is out!

Professor Jennifer Mitchell is the recipient of the inaugural Dorothy Shoichet Women Faculty in Science Award of Excellence.

Virlana Shchuka has been awarded a PGS-D fellowship from NSERC, awarded to high-calibre students who are engaged in doctoral programs in the natural sciences or engineering.

Congratulations to Virlana Shchuka on receiving the Duncan L. Gellatly Memorial Award for excellence in research.

OIRM New Ideas grant on 'Activating enhancers to improve reprogramming efficiency' awarded to the Mitchell Lab.

Mitchell Lab receives an NSERC Discovery Grant.

U of T Cell Biologists Discover On-Off Switch for Key Stem Cell Gene

Key stem cell gene controlled from afar, Canadian scientists discover


CIHR NSERC Ontario Research Fund CFI