Our Research

Our main experimental system is yeast, because it enable us to ask questions that are relevant to all Eukaryotic organisms, including humans, while using high throughput experimental approaches that include directed evolution, synthetic biology, cell sorting and next generation sequencing. Our current research interests are:

1. Evolution of Signaling Networks
Signaling networks’ functions are altered by genetic change. Some changes may lead to adaptive evolution. We are investigating how mutations, such as gene duplication, recombination, or amino acid substitutions, affect the function of signaling networks.

2. Signaling Network Malfunction and Disease
While some mutations are beneficial, many others are detrimental, sometimes leading to disease. For instance, cancer often arises from mutations in signaling pathways that control cell growth. We are developing high-throughput model systems to investigate the relationship between signaling network malfunction and disease.

3. Synthetic Biology of Signaling Networks
The ability to precisely control the function of signaling networks will open the door to endless biotechnological applications, including cell-based therapies, biosensors or microbiological platforms for the production of biochemicals and biofuels. We are developing synthetic biology methods based on the unique bioengineering abilities of evolution.